Genetic and epigenetic determinants of inter-individual variability in responses to toxicants

Genetic and Epigenetic Determinants of Susceptibility to Environmental and Occupational Toxicants

: 26 Biomarkers of Testicular Injury: Where Have We Been (B McIntyre) 9:30 AM 12:30 PM, Exhibit Hall C-D (CC), Poster Session Bioinformatics and Computational Toxicology: Systems and Strategies Abstract #: 115, Poster Board #: 201 Effect of Technical Variation and Bioinformatics on the Biological Discovery in a Mechanistic Toxicogenomics Study (B Gong, J Xu, Z Su, H Hong, J Meehan, H Fang, W Ge...

Combinations of susceptible genotypes and individual responses to toxicants.

The variation in individual responses to exogenous agents has been shown to be exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in environmentally induced cancer or other diseases in which an en...

Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population

Genetic and Epigenetic Determinants in Autoinflammatory Diseases

The concept of autoinflammation has evolved over the past 20 years, beginning with the discovery that mutations in the Mediterranean Fever (MEFV) gene were causative of Familial Mediterranean Fever. Currently, autoinflammatory diseases comprise a wide range of disorders with the common features of recurrent fever attacks, prevalence of hyperreactive innate immune cells, and signs of inflammatio...

Genetic and acquired determinants of individual variability of response to antiplatelet drugs.

Individual heterogeneity in responsiveness to antiplatelet agents may be due to either inherited or acquired factors. These potential variables include genetic polymorphisms in platelet proteins targeted by the drugs, differences in their pharmacokinetics, drug or other environmental interactions, and the baseline state of platelet function before initiation of treatment. With regard to the lat...